TTR and neoplasm: We thus examined the following issues: (i) the effects of various covariates on gene expression; (ii) the association of TTR with transcriptomic/genomic differences between paired P-R GBMs; (iii) the association of TTR with cellular heterogeneity between paired P-R GBMs; (iv) the correlation between paired P-R GBMs in gene expression profiles and tumor mutation burden (TMB); and (v) the relationship of TTR to the P-R correlation observed in (iv).