On the basis of the 55 TTR-associated genes, we performed the ConsensusClusterPlus analysis [41] and precisely divided primary GBM patients (87 cases) into two different groups (Group 1 and Group 2), in which Group 1 and Group 2 accounted for 39 and 48 cases, respectively (Fig. 5B and Additional file 4: Table S4). This evidence concerns the gene TTR and glioblastoma.