These opposite effects of LLPS on the two integrase enzymatic activities were surprising at first glance but may reflect that the two IN activities were investigated independently in vitro whereas in vivo, they follow the dynamics of the infection cycle: it’s obvious that in infected cells, these two reactions occur sequentially (the strand transfer reaction required that the 3′ processing activity is achieved) and not in the same environment, neither the same temporality. Here, CD44 is linked to infection.