Of note, there was a positive linear correlation between Fendrr expression and the extent of liver fibrosis, as well as the mRNA expression of α-SMA and collagen I (Col I) in the specimens of liver cirrhosis patients (Figs. 1H and S3C), suggesting that the increase of Fendrr is clinically involved in the progression of HSC activation and liver fibrosis. This evidence concerns the gene ACTA1 and cirrhosis of liver.