FENDRR and fibrosis: We then tested whether knockdown of hepatocyte Fendrr would prevent liver fibrosis by intravenously injecting the lentivirus 2 days prior to the first injection of CCl4. By 4 weeks of CCl4-treatment, the CCl4-treated liver displayed a typical feature of fibrosis, whereas delivery of the Fendrr shRNA lentivirus greatly alleviated the severity of fibrosis and reduced the fibrotic area and hepatic hydroxyproline content (Fig. 3, A–C).