Consistent with the expression profile of CSNK2A1 and HTATSF1 from the TCGA and GEO data, quantitative analysis of IHC staining showed that the level of pS748 was significantly elevated in carcinoma samples, and it is positively correlated with the malignant degree (grades) of breast cancer samples (Fig. 2D), although it does not well reflect tumor stages, a comprehensive index of primary tumor size and distant metastasis (Fig. 2E). The gene discussed is HTATSF1; the disease is neoplasm.