To address this question, a study using mouse models with either MAVS global knockout or hepatocyte-specific MAVS knockout reported that these mice were more prone to developing diet-induced NAFLD.16 In contrast, we found in this study that adult-onset MAVS inhibition in the whole liver or specifically in hepatocytes protected mice against diet-induced MASLD. This evidence concerns the gene MAVS and metabolic dysfunction-associated steatotic liver disease.