WD-fed mice also displayed a significant glucose intolerance (Supplemental Figure S6C, http://links.lww.com/HEP/I457) and insulin resistance (Supplemental Figure S6D, http://links.lww.com/HEP/I457), which were improved upon hepatic knockdown of MAVS (Supplemental Figures S6C, D, http://links.lww.com/HEP/I457), as well as reduced circulating AST and ALT, collagen content (as shown by Sirius Red staining), and the expression of markers of fibrosis and inflammation when compared to control mice fed a WD (Supplemental Figures S6E–I, http://links.lww.com/HEP/I457). The gene discussed is MAVS; the disease is Insulin resistance.