In a unique post hoc analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study, in which all on-study incident fractures were collected as part of the strict trial protocol and participants with type 2 diabetes were extensively characterised metabolically, we found independent associations between any fracture and macrovascular disease and HDL-cholesterol in men, between any fracture and neuropathy in women, and between any fracture and insulin therapy in both [28]. Here, INS is linked to type 2 diabetes mellitus.