Increased risk may occur only in subsets of individuals with type 2 diabetes, including insulin users [5, 7], those with either a short [5, 8] or longer [5] duration of type 2 diabetes diagnosis or those with HbA1c levels <53 mmol/mol (7%) [9] or >75 mmol/mol (9%) [10]. Here, INS is linked to type 2 diabetes mellitus.