TP53 and cholestasis: To further evaluate the inflammatory state of liver tissue during ANIT-induced cholestasis, before and after vincamine treatment, mRNA levels of TNFα, IL-6, IL-1β, NF-kB, Klf6, PDGF, PPARγ, and p53 were examined as well as the protein levels of the PPARγ target candidates, catalase and HO-1.