MAPT and Alzheimer disease: In brain extracts from AD patients, many of the antibodies (e.g. 5A6, DA9, Tau-5, D1M9X, Tau-46, C-term ab254256, K9JA) also detected high-MW smears, as well as distinct bands of ~ 150–180 kDa, widely reported features of AD brain protein extracts, which can be attributed to the presence of PHF-Tau aggregates and low-order oligomers, respectively (Supp.