While λPP has been used successfully in vitro to dephosphorylate PHF-Tau extracted from AD human brains [71], to the best of our knowledge, it has not previously been used to dephosphorylate Tau in situ and, thus, its efficiency towards different types of Tau aggregates in FFPE tissue sections is yet to be characterised. The gene discussed is MAPT; the disease is Alzheimer disease.