We were intrigued by the unexpected finding that neither TOMA-1 nor T22-purified detected oligomeric Tau in tauopathy brain extracts, given that many of the “total” Tau and phospho-Tau antibodies, including the well-established AT8 and AT180 antibodies, immunoreacted strongly with high-MW Tau species in AD brain extracts (column VI in Supp Figs. S4-S7 and Supp. This evidence concerns the gene MAPT and tauopathy.