The alteration of key proteins, including PD-1 and XBP-1, in response to PDIA3 overexpression or suppression, corroborated the pivotal role of PDIA3 in tumor-associated macrophage polarization and protease production, as confirmed by Western blotting and the effect of PD-1 antibodies in these processes. Here, XBP1 is linked to neoplasm.