PDIA3’s relationship with cancerous transformation and progression are both intimate and insidious, with heightened expression levels detected in a gamut of malignancies, including diffuse glioma [11], clear cell renal cell carcinoma [12], hepatocellular carcinoma (HCC) [13], breast cancer [14], cervical cancer [15], and gastric cancer [16], an overexpression which traditionally signals a grim prognosis. The gene discussed is PDIA3; the disease is hepatocellular carcinoma.