Notably, compared with the saline group, BLM remarkably induced lung parenchymal fibrotic lesions in mice, while the administration of AAV2/9-Flag-Cct6a attenuated BLM-mediated lung fibrosis, as shown by hydroxyproline assays, H&E and Masson's trichrome staining (Figure 6B and F). This evidence concerns the gene CCT6A and pulmonary fibrosis.