Alternatively, the coupling of increased CSF sTREM2 and CSF/plasma albumin ratio may be indicative of increased permeability of the choroid plexus (blood-CSF barrier) to solutes which is known to occur in AD [45], and subsequently, the increased accumulation of sTREM2 in CSF which had originated in plasma having been cleaved in peripheral tissues. The gene discussed is ALB; the disease is Alzheimer disease.