INS and myotonic dystrophy type 1: Deficient insulin signaling contributes to mTOR/AKT downregulation in DM1, which may fail to activate sterol regulatory element binding protein 1c (SREBP-1 C), a direct transcriptional regulator of fatty acids synthesis genes and dependent of [72–74] This hypothesis is supported by our results, where we observed that adding an LXR agonist to DM1 cells is sufficient to restore OA levels.