The dissociation of accelerated aging phenotypes and cancer also applies to defects in lamin A/C, e.g. Hutchinson-Gilford progeria syndrome (HGPS) due to mutations in lamin A encoded by LMNA or its protease STE24 encoded by ZMPSTE24 [17]. The gene discussed is ZMPSTE24; the disease is Hutchinson-Gilford progeria syndrome.