Mediators derived from cancer cells and their surrounding stromal cells, such as IL-6, PGE2, TGF-β, hyaluronic acid fragments (HA), and G-CSF/GM-CSF, contribute to the reprogramming of neutrophils into a tumor-promoting phenotype [16, 25, 120, 123, 124]. The gene discussed is TGFB1; the disease is neoplasm.