TLR4 and neoplasm: Exosome transporter high-mobility group box 1 (HMGB1) derived from gastric cancer cells induces neutrophil autophagy via the HMGB1/Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway, releasing pro-tumor cell migration factors, such as IL-1β and OSM [63].