As shown in Fig. 5A, B, ELISA revealed a significant increase in TNF-α and IL-1β levels in cortical and hippocampal tissues on both the first and seventh day after sepsis induction (****p < 0.0001, ****p < 0.0001, ****p < 0.0001, ****p < 0.0001 vs. sham group), OXA treatment significantly reduced the expression levels of TNF-α and IL-1β (***p < 0.001, **p < 0.01, ****p < 0.0001, *p < 0.05, ***p < 0.001, ****p < 0.0001 vs. CLP group). The gene discussed is TNF; the disease is Sepsis.