After 7 days of odontogenic induction, the protein expression levels of DSPP, DMP-1, ALP, and Runx2 were significantly increased in DPSCs treated with CM-EV and OM-EV, and the expression of DSPP and Runx2 was significantly higher in OM-EV group compared with CM-EV group (see Fig. 4E and F). Here, RUNX2 is linked to ocular melanoma.