Other mainly controllable adverse events such as thrombocytopenia, anemia, neutropenia, leukopenia, pruritus, rash, hand-foot syndrome, elevated AST/ALT, fatigue, nausea and vomiting, diarrhea, hypertension, proteinuria, and reactive cutaneous capillary endothelial cell proliferation, among others, did not result in serious adverse outcomes or lead to mortality. This evidence concerns the gene GPT and Hand-foot syndrome.