SPRY3 and non-small cell lung carcinoma: In male non-small cell lung cancer cells, linc-SPRY3-2/3/4 has been found to interact with IGF2BP3, resulting in a decrease in the stability of specific IGF2BP3 binding mRNAs like anti-apoptotic HMGA2 mRNA and oncogenic c-MYC mRNA (Brownmiller et al. 2020).