The CTNNB1 gene (encoding for β-catenin) is mutated in approximately one-third of HCC, described as low-grade trabecular-acinar tumors by the original work by Calderaro et al. [13] The frequency of TP53 mutations in HCC is variable according to the series considered in the literature, from 15 to 40%: TP53 mutation characterizes high-grade, more aggressive HCC, and it was correlated to aflatoxin exposure and HBV infection [10, 13]. This evidence concerns the gene TP53 and hepatocellular carcinoma.