The existence of a robust association between RUNX2 11A and the prevalence of nsSag would have major significance for understanding the pathogenesis of non‐syndromic craniosynostosis, so we decided to reinvestigate these observations, with the aim of first, establishing a reliable background allele frequency (AF) of 11A in the NFE population, and second, genotyping an independent cohort of nsSag and nsMet subjects, to see if we could replicate the original findings. Here, RUNX2 is linked to craniosynostosis.