RBFOX3 and glioblastoma: The analysis, which included glioblastoma tissue, matching tumor monocultures (n = 17), healthy cortex (n = 9) and sorted NeuN+ cells (n = 5), confirmed a higher stem-cell-like signature in glioblastoma tissue and cell cultures (Extended Data Fig. 3f) and the distinct neuronal signature in NeuN+ cells and healthy cortex (Extended Data Fig. 3g).