Furthermore, spatial transcriptomic data highlighted a co-localisation of VEGF-NOTCH signalling and the interactions among the foetal-associated PLVAP+ /VEGFR2+ endothelial cells, embryonic-like FOLR2+ /CD163+ TAMs and immunosuppressive regulatory T cells (CTLA4) that maintained an immunosuppressive tumour microenvironment in HCC [48]. The gene discussed is CTLA4; the disease is hepatocellular carcinoma.