Another integrated analysis of histopathological examination, mutational analysis, single-cell RNA-Seq, single-cell TCR-Seq, and spatial TCR imaging revealed the unique immunophenotypes of CXCL13+ PD1+ CD4+ T helper and GZMK+ PD1+ effector-like CD8+ cells in the HCC tumour microenvironment of responders treated with neoadjuvant anti-PD1 [87]. Here, CD4 is linked to hepatocellular carcinoma.