Furthermore, A review recently supported that the abnormal activity of UGT1A1 not only has a tight correlation with Gilbert syndrome and Crigler–Najjar syndrome but also may be related to bilirubin-induced encephalopathy, Alzheimer’s disease, hepatobiliary diseases, cholestasis and some other diseases, among most of which are due to bilirubin metabolism31. Here, UGT1A1 is linked to Gilbert syndrome.