In addition, for the genotype of lipid metabolism in male schizophrenia patients (Fig. 4E), the level of CHOL in INSIG1 (rs9769826) genotype (ANOVA: F(4,95) = 2.847, p = 0.028; INSIG1 vs. wild type: p = 0.023; INSIG1 vs. SREBF2: p = 0.046) was significantly higher than in wild type and the SREBF2 (rs1052717) genotype and the level of LDL-CH in INSIG1 (rs9769826) genotype (ANOVA: F(4,96) = 3.003, p = 0.022; INSIG1 vs. wild type: p = 0.031) was significantly higher than wild type. The gene discussed is C4B; the disease is schizophrenia.