In 150 non-invasive (pT1) and invasive (pT2/pT3/pT4) GC, high NUCB2 IHC scores were significantly associated with unfavorable prognostic factors including deep invasion, lymph-vascular tumor invasion, lymph node metastasis, and advanced clinical stage (Table 1). The gene discussed is NUCB2; the disease is metastatic malignant neoplasm in the lymph nodes.