Most importantly, however, loss of DJ-1 leads to a drastic inner mitochondrial membrane depolarization, which could be restored by supplementing GA and/or DL (Toyoda et al, 2014), making them ideal candidates for restoration of above-mentioned SOD1- and particularly FUS-ALS-induced inner mitochondrial membrane depolarization phenotypes. Here, PARK7 is linked to amyotrophic lateral sclerosis.