We finally used CRISPR/CAS9 gene-edited iPSC-derived spinal MNs (Table 1) either expressing WT or P525L FUS-eGFP and proved that 10 mM co-treatment with GA and DL was also able to restore FUS recruitment to laser-irradiated DNA damage sites in spinal MNs (Fig 2E and F) as well as the cytosolic mislocalization of FUS in the mutant (Fig S6A and B), thereby validating our findings in the HeLa ALS-FUS model (Fig 2A–D). Here, FUS is linked to amyotrophic lateral sclerosis.