Interestingly, Riluzole had no effect on any of the parameters investigated, which included mitochondrial and lysosomal trafficking (Fig S7A–C), mitochondrial inner membrane potential (Fig S7E) and mitochondrial fragmentation (FUS-ALS) or elongation (SOD1-ALS) (Fig S7D). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.