We present novel insights into the pathophysiology of Superoxide Dismutase 1 (SOD1)- and in particular Fused In Sarcoma (FUS)-ALS by revealing a supposedly central role of glycolic acid (GA) and D-lactic acid (DL)—both putative products of the Parkinson’s disease associated glyoxylase DJ-1. The gene discussed is SOD1; the disease is Parkinson disease.