After univariate analysis (Table 2), multivariable Cox regression demonstrated that after adjusting for the influence of age, the overexpression of NEK2 was one of the independent and important prognostic variables for OS in patients with ccRCC (HR = 1.29, P < .001) (Supplementary Figure 4, http://links.lww.com/MD/M258). Here, NEK2 is linked to nonpapillary renal cell carcinoma.