In contrast, in ccRCC samples, KDR (Cor = -0.26, P < .0001), PVRL2 (Cor = -0.112, P < .01), TNFRSF4 (Cor = -0.227, P < .0001) and CX3CL1 (Cor = -0.349, P < .0001) all displayed significant negative correlations with NEK2. The gene discussed is TNFRSF4; the disease is nonpapillary renal cell carcinoma.