NEK2 and nonpapillary renal cell carcinoma: NEK2 was also linked to prognosis in various malignancies, including pancreatic cancer, hepatocellular cancer, nasopharyngeal cancer, gastric cancer, colorectal cancer, and breast cancer.[37–44] We analyzed NEK2 expression between various tumor stages to better understand the role of NEK2 in the development of ccRCC.