Studies have shown that the TNF family of cytokines and their receptors such as tumor necrosis factor receptor-associated factor 2 and TNF-like ligand 1A are associated with the prognosis of gastric cancer.[45,46] In addition, NOX4 predicts a poor prognosis of gastric cancer patients.[47,48] However, the prognostic values of DUSP1 and LONP1 remain unclear. The gene discussed is LONP1; the disease is gastric cancer.