IGHE and immune system disorder: Connections between IgE immune responses and defense against cancers were first reported in the 1960s,[23] and numerous studies have pointed to IgE involvement in natural antitumor immunosurveillance.[24,25] Significant epidemiological data suggest that IgE, allergy, and atopy may play protective roles against specific tumor types, with an increased risk associated with IgE immunodeficiency.[26]