We also found that the crizotinib-resistant cell lines conferred cross-resistance to tepotinib, and the IC50 values were 0.006 ± 0.01, 8.062 ± 0.00 and 7.635 ± 0.06 μM ± SD in EBC-1 parental, CRH, and CRS cells, respectively, and 0.065 ± 0.09, 9.375 ± NA and 5.05 ± 0.07 μM ± SD in H1933 parental, CRS, and CRH cells, respectively. Here, CRH is linked to congenital rubella syndrome.