BAP1 and neoplasm: In approximately 50% of UM patients, BRCA1 associated protein-1, BAP1, (ubiquitin carboxy-terminal hydrolase), a deubiquitinating enzyme, is mutated inactive, i.e., BAP1 is a tumor suppressor, and its loss of function subsequently was also associated with BAP1 acting as a suppressor of metastatic spread [17–20].