Notably, previous studies has reported that HIF-1 inhibits PGC-1α–mediated mitochondrial biogenesis by repression of myelocytomatosis viral oncogene homolog (C-MYC) activity in von hippel-lindau (VHL)–deficient renal cell carcinoma (51) or through basic-helix-loop-helix transcription factor Dec1 in VHL-deficient clear-cell renal cell carcinoma (52). Here, VHL is linked to clear cell renal carcinoma.