P2RY12 and neoplasm: IMC allowed us to putatively identify microglia (iba1+, TMEM119+, and P2RY12+) and tumor-associated macrophages (iba1+ and CD163+) based on their morphology and marker expression, as well as cells positive for markers of central nervous system (CNS) progenitor cells and cellular proliferation often associated with neoplastic cells (CD44, SOX2, Olig2, and Ki67) (Fig. 1B).