CASP8 and neoplasm: Similarly, the expression of CA-IX and Bcl-2 members family (regulators of apoptosis in tumor cells) including RTRAIL-R2, RTRAIL-R4, caspase-8, cFLIP, Bak, Bcl-XL, and Mcl-1 did not associate with OS or PFS of meningioma patients (p>0.05) [55, 70].