MRE11 was also among the cancer genes significantly enriched for SVs in TWT tumors compared with other subtypes (Fisher’s exact, OR = 5.36, 95% CI = 1.01–25.18, P = 0.024); it is one of the core genes of the MRN complex, along with NBN and RAD50, is involved in the initial processes of DSB repair prior to homologous recombination and NHEJ, and is responsible for activating ATM (40, 41). Here, RAD50 is linked to cancer.