BRAF and melanoma: For example, one BRAF-mutant melanoma harbored an intrachromosomal chromothripsis event that affected the BRAF locus (Figure 2E), while 4 other BRAF-mutant melanomas harbored chromothripsis events that spanned (i.e., the gene is at least partially between the breakpoints of at least 1 chromothripsis-generated SV) NRAS.