NF1-mutant melanomas were significantly associated with non-duplication SV events in two RASopathy genes, RAF1 and SPRED1 (Fisher’s exact, OR = 5.03, 95% CI = 1.46–16.42, P = 4.8 × 10–3), the latter of which has also been identified as a significantly mutated gene exclusive to NF1-mutant melanomas (10, 37). Here, SPRED1 is linked to melanoma.