The most statistically significant canonical cancer gene affected by SVs in TWT melanomas was CBFA2T3, which was not altered in any of the other genomic subtypes (Fisher’s exact, OR = infinity, 95% CI = 5.69–infinity, P = 1.3 × 10–4) and is a putative tumor suppressor in breast cancer (38, 39). This evidence concerns the gene CBFA2T3 and cancer.