In the Dutch, the most common genes related to LGMD spectrum were CAPN3, SGCA/B/G/D, ANO5 accounting for nearly 70%, whereas the remaining genes included FKRP, EMD, GMPPB, contraction of D4Z4 repeat, SMN1, FLNC, MICU1, TRIM32 [28]. The gene discussed is EMD; the disease is limb-girdle muscular dystrophy.