Consistent with these findings, the onset of acute cardiac events is significantly associated with a more severe course of the disease (NIV, intubation and mechanical ventilation, ECMO-ECLS, ICU therapy, ICU duration), more inflammation (sepsis, higher CRP levels, pulmonary superinfection), organ failure (quantitative chest CT lesions, renal failure), and mortality. The gene discussed is CRP; the disease is Sepsis.