TP53 and benign neoplasm: ROC analysis comparing the three classifiers showed that the binary classifier of the fraction of LOH greater than 0.11 segregated treatment-refractory from benign tumors slightly more successfully (AUC = 0.87) than the random forest model (AUC = 0.86), and much better than TP53 mutational status alone (AUC = 0.75), Supplementary Fig. 4b–d.