In L-sarcomas, HMGA1 strong intensity was significantly associated with worse PFS [3.2 months (95% CI 2.0–4.4) vs. 5.6 months (95% CI 4.1–7.1), p = 0.008] and worse OS [10.5 months (95% CI 0.8–20.2) vs. 21.8 months (95% CI 16.0–27.6), p = 0.017]. The gene discussed is HMGA1; the disease is sarcoma.