In line with these observations, it has been recently reported that the HMGA2/IGF2BP/IGF2/IGF1R/AKT/mTOR axis was typically upregulated in capicua-double homeobox 4 (CIC-DUX4)–rearranged sarcomas and renders these tumors sensitive to the combination of trabectedin with PI3K/mTOR inhibitors [53]. The gene discussed is DUX4; the disease is sarcoma.