Although tumor histology may justify the different results observed between our study and these publications, we need to take also into account the experimental context (human samples vs. cell lines and immunosuppressed mice model) in the case of D’Angelo and colleagues work [30], and the role of HMGA1 in modulating inflammation and milieu-associated CSCs [36], which may ultimately affect the sensitivity to drug treatment. Here, HMGA1 is linked to neoplasm.