Meanwhile, MUC16 can also activate c-Myc in pancreatic cancer, up-regulate the expression of c-Myc, enhance the binding of c-Myc to E-box in the promoter of microRNA-29a (miR-29a) (which is the downstream target of FBW7 gene), and inhibit the transcription of miR-29a. Here, MUC16 is linked to familial pancreatic carcinoma.