In PDAC, the deletion of glycosyltransferase Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-Beta-Galactosyltransferase 1 (C1GALT1) and its molecular chaperone Cosmc are both mechanisms leading to increased expression of truncated O-glycochains and increased tumor aggressiveness. This evidence concerns the gene C1GALT1 and neoplasm.