JAK2 and pachyonychia congenita: In PC cells, the carboxyl terminal of MUC16 can be cleaved to produce a 17 kDa cleaved MUC16 (MUC16-cter), Janus Kinase 2 (JAK2) nuclear shift induced by MUC16-Cter can upregulate stem specific genes such as LIM domain Only 2 (LMO2) and Nanog Homeobox (NANOG) to promote proliferation, metastasis and chemotherapeutic resistance of PC cells (reduced cytotoxic response to chemotherapy drugs) [60].