MUC16 up-regulates the expression of Testis-Specific Y-Encoded-Like Protein 5 (TSPYL5) in lung cancer through the JAK/STAT3/glucocorticoid receptor (GR) signaling pathway, and the upregulation of TSPYL5 inhibits the expression of p53 and related genes, thus promoting the growth of lung cancer cells and cisplatin resistance (Fig. 4) [63]. Here, MUC16 is linked to lung cancer.