MUC16 mutations are often detected in Epstein–Barr virus (EBV) associated lymphoepithelioma-like cholangiocarcinoma (EBV-LELCC), which is a rare subtype of intrahepatic cholangiocarcinoma (IHCC) [17] and in the rare disease primary malignant melanoma of the esophagus (PMME) [18], suggesting that the patient may be a special type of cancer. The gene discussed is MUC16; the disease is cancer.