We identified six proteins with potentially causal associations, and four are currently druggable targets (FCG2B, IGFBP3, CAH6, ASGR1).28 Applying machine learning, we developed and validated proteomic risk models for HF, and protein models for short- and long-term HF, and for HFrEF, that surpass the extensively validated PCP-HF model39,40 among patients with CKD (Structured Graphical Abstract). Here, IGFBP3 is linked to hydrops fetalis.