IGFBP3 and heart failure: Utilizing summary data from the Heart Failure Molecular Epidemiology for Therapeutic Targets (HERMES) Consortium genome-wide association study, two-sample MR suggested causal relationships for six proteins significant at FDR < 0.2 (corresponding to P < .05), including low affinity immunoglobulin gamma Fc region receptor II-b (FCG2B), insulin-like growth factor-binding protein 3 (IGFBP-3), macrophage scavenger receptor types I and II23 (MSRE), carbonic anhydrase (CAH6), Fc receptor-like protein 4 (FCRL4), and asialoglycoprotein receptor 1 (ASGR1) (Figure 2).