Overall, 16 proteins replicated for the association with general HF adjusted for eGFR, including ephrin type-A receptor 2,20 and also relatively novel proteins related to the extracellular matrix (ECM) such as WAP four-disulfide core domain protein 221 and microfibril-associated glycoprotein 422 (MFAP4) (Table 2). Here, EPHA2 is linked to hydrops fetalis.