PROM2 and heart disorder: While older individuals without cardiomyopathy showed a trend for increased Prom2 mRNA expression compared to young individuals, this change became significant only in the group of old individuals with HFpEF (Figure 2b), a very common aged‐related cardiac disease characterized by ventricular stiffness and impaired relaxation, together with preserved systolic function (Lazzarini et al., 2013).