We demonstrated that NP-ICG-HAscan bind to 4T1 breast cancer cells through CD44/HA interactions.Moreover, NP-ICG-HAs target CD44 expressing breast tumors in the MMTV-PyMTmouse model, and CD44 expressing breast cancer cells in the lung in4T1 inoculated BALB/c mice. Here, CD44 is linked to breast cancer.