CXCL12 and neoplasm: Notably, among these pro‐tumor factors, we found two secreted chemokine genes, Cxcl1 and Cxcl12, were consistently down‐regulated in the Mg‐CaCO3 group (relative expression level of group V: Cxcl1: 0.1757, Cxcl12: 0.1154) (Figure 4e).