IRF1 and neoplasm: As mentioned above, Nos2 was a stress‐induced gene, which could be up‐regulated by ROS signal and then regulate down‐stream pro‐tumor factors expression.[26] We confirmed that the expression levels of Nos2 and its reported transcription factor (TF) Irf1 significantly decreased after the Mg‐OPSZ and Mg‐CaCO3 treatment,[32] while Mg‐CaCO3 showed a better inhibition effect (Figure 4c).