Moreover, the immune stimulating factors ifn‐γ and tnf‐α in the serum are key elements for anti‐tumor efficiency.[41, 42] We found a higher level of ifn‐γ and tnf‐α in the Ctrl group in MC38 cell model than 4T1 cell model (4T1: ifn‐γ: 7.736, tnf‐α: 6.780; MC38: ifn‐γ: 20.96, tnf‐α: 17.73) (Figure 6q,r; Figure S28, Supporting Information), which further supported an activated immune status of MC38 cell model. Here, TNF is linked to neoplasm.