In addition, no correlation was observed between DEF and p53 expression (Pearson's r = 0.24, p = 0.0012) or between p53 and calpain3 expression (Person's r = 0.11, p = 0.12) in pancreatic cancers (Figure S2c, Supporting Information). The gene discussed is TP53; the disease is familial pancreatic carcinoma.