To evaluate the relevance of DEF in pancreatic cancer, we selected distinct cell lines: PANC1, a human PDAC cell line harboring a p53 mutation; HPAC, a human PDAC cell line expressing wild‐type p53; and KPC, a cell line derived from KRAS LSL‐G12D;TP53LSL‐R172H; Pdx1‐Cre (KPC) mice with PDAC. This evidence concerns the gene KRAS and pancreatic neoplasm.