MAPK8 and colonic neoplasm: In agreement with its oncogenic function, it has been reported that an eicosanoid metabolite named as 12,13‐epoxyoctadecenoic acid (EpOME), produced from linoleic acid by CYP monooxygenase, enhanced the JNK phosphorylation and cytokine production and contributed to the development of AOM‐DSS‐induced colon tumors in vivo.[50] Indeed, we observed that conditional deletion of Selenoi in intestinal epithelial cells resulted in a reduction of Cyp2d9, a CYP monooxygenase for the synthesis of 12,13‐EpOME.