OPA1 and neurodegenerative disease: Since Opa1 plays a critical role in the regulation of mitochondrial structure and function and is implicated in a number of neurodegenerative diseases (Alavi & Fuhrmann, 2013; Frezza et al., 2006; Patten et al., 2014), we generated an Opa1‐inducible knockout in adult NSCs as a model to study the effects of mitochondrial dysfunction on adult neurogenesis (Kane et al., 2017; Ramonet et al., 2013).