Bilirubin flows through the blood over time and gradually enters the cell through the uptake system, continuously binding to the target receptor PPARα within the cell, resulting in core pressurized protein translated into coactivators to activate transcriptional control of the genes, which can further increase the downstream fat burning, improve insulin resistance and lipid metabolism disorders, regulate blood glucose levels, and thus play a role in delaying the progression of DN. The gene discussed is PPARA; the disease is Insulin resistance.