Similarly, we observed severe to moderate pathology in the H37Rv-infected chronic model of mice lungs (Figure 2H). In PRK treatment groups, in both acute and chronic models of infection, we observed minimum pathology with large areas with normal alveolar space (Figures 2G, H). Granuloma scores and histopathology scores were observed to be consistent with bacterial infection and PRK treatment in the acute H37Rv control and acute PRK treated groups (Figure 2I, J) as well as the chronic H37Rv control and chronic PRK treated groups (Figures 2K, L), respectively. This evidence concerns the gene PLK3 and Granuloma.