PLK3 and infection: For the chronic model of infection, 4-6 weeks female BALB/c mice were infected via aerosol through a Madison chamber aerosol generation instrument calibrated to deliver 100 CFU, then mice were housed for 4 weeks of incubation for the establishment of infection, and after 4 weeks of post-infection, the mice were randomly grouped (n=6) as H37Rv Control group and PRK Treatment group, (PRK; 5 doses weekly@ 40mg/kg.b.wt through oral route), and on the 8th week of post-infection (p.i.), the mice were humanely sacrificed for accessing bacterial load in the lungs.