Another mechanism of pancreatic cancer may be that the three red complexes of P. gingivalis, treponema dentalis and Forsythian bacteria produce peptidyl arginine deiminase PAD enzyme that degrades arginine, which causes p53 and K-Ras point mutations, leading to pancreatic cancer (Wei et al., 2019). Here, TP53 is linked to familial pancreatic carcinoma.