Causing chronic gastritis and leading to gastric ulcers and atrophy, Persistent infection leads to cell damage of Gastric mucosa, cancer transformation; Deactivate ARID1A gene, resulting in cell Mitosis defect; Toxicity factors directly regulate the function of gastric epithelial cells and cause inflammation; Indirectly affect gastric epithelial cells, causing gastric ulcers. This evidence concerns the gene ARID1A and cancer.