SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Analogously in the context of Dravet syndrome, a severe epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, Valassina et al. recently proposed a conditional knock-in mouse model enabling on-demand Scn1a reactivation, via a floxed STOP cassette removal.